Lorazepam, sold under the brand name Ativan among others, is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal, and chemotherapy induced nausea and vomiting, as well as for surgery to interfere with memory formation and.
Lorazepam has anxiolytic, sedative, hypnotic, amnesic, anticonvulsant, and muscle relaxant properties. It is a high-potency and an intermediate-acting benzodiazepine, and its uniqueness, advantages, and disadvantages are largely explained by its pharmacokinetic properties (poor water and lipid solubility, high protein binding and anoxidative metabolism to a pharmacologically inactive glucuronide form) and by its high relative potency (lorazepam 1 mg is equal in effect to diazepam 10 mg). The biological half-life of lorazepam is 10–20 hours.
Also, one must ascertain whether other substances were also ingested.
More Info For This Drug. View Label Archives; RxNorm; Get Label RSS Feed. NDC Code(s): ; Packager: RedPharm Drug Inc. This is a repackaged label. Source NDC Code(s): . Category: HUMAN PRESCRIPTION DRUG LABEL; DEA Schedule: CIV; Marketing Status: Abbreviated New Drug.
Safety and effectiveness of lorazepam in children of less than 12 years have not been established.
Studies comparing young and elderly subjects have shown that advancing age does not have a significant effect on the pharmacokinetics of lorazepam. However, in one study involving single intravenous doses of 1.5 to 3 mg of lorazepam injection, mean total body clearance of lorazepam decreased by 20% in 15 elderly subjects of 60 to 84 years of age compared to that in 15 younger subjects of 19 to 38 years of age.
Lorazepam dosage should be reduced to approximay 50% when coadministered with valproate.
Category: HUMAN PRESCRIPTION DRUG LABEL; DEA Schedule: CIV; Marketing Status: Abbreviated New Drug Application Studies in healthy volunteers show that in single high doses lorazepam has a tranquilizing action on the central nervous system with no appreciable effect on the respiratory or Studies in healthy.
Age does not appear to have a significant effect on lorazepam kinetics (see CLINICAL PHARMACOLOGY ).
Overdosage of benzodiazepines is usually manifested by varying degrees of central nervous system depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, mental confusion, paradoxical reactions, dysarthria, and lethargy. In more serious cases, and especially when other drugs or alcohol were ingested, symptoms may include ataxia, hypotonia, hypotension, cardiovascular depression, respiratory depression, hypnotic state, coma, and death.
Lorazepam has been detected in human breast milk; therefore, it should not be administered to breast-feeding women, unless the expected benefit to the woman outweighs the potential risk to the infant.
Examples of Schedule IV substances include: alprazolam (Xanax), carisoprodol (Soma), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), and triazolam (Halcion).
Substances in this schedule have a low potential for abuse relative to substances listed in Schedule IV and consist primarily of preparations containing limited quantities of certain narcotics.
A substance (not included on these lists) may also be regulated as a controlled substance analogue. See 21 U.S.C. §813 for the schedule. §802 (32)(A) for the definition of a controlled substance analogue and 21 U.S.C. A controlled substance analogue is a substance which is intended for human consumption, is structurally substantially similar to a schedule I or schedule II substance, is pharmacologically substantially similar to a schedule I or schedule II substance, or is represented as being similar to a schedule I or schedule II substance and is not an approved medication in the United States.
Some examples of substances listed in Schedule I are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), peyote, methaqualone, and 3,4-methylenedioxymethamphetamine ("Ecstasy").
Section 812 of the Controlled Substances Act ( 21 U.S.C.
The Controlled Substances Act (CSA), part of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal cornerstone of the government's war against drug abuse. The U.S. Drug Enforcement Administration (DEA) has divided these substances into five categories, called “schedules,”.
*Editor's Note: The AAP policy statement, " The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update, " recommends rescheduling marijuana from a Schedule 1 (I) to a Schedule 2 (II) drug. See Legalizing Marijuana Not Good for Kids: AAP Policy Explained. This is because some of the active ingredients in the marijuana (cannabis) plant, called cannabinoids, have been shown, in limited research, to have medical benefit for some particular conditions in adults, such as helping control nausea and vomiting due to cancer chemotherapy, or specific chronic pain syndromes.
This site complies with the HONcode standard for trustworthy health information: verify here.
Schedule 5 (V) drugs are generally used for antidiarrheal, antitussive, and analgesic purposes.