The most common signs of a carisoprodol overdose are euphoria, mood alternations, and dilated pupils. Very serious overdoses may.
This situation may increase the chances of overdose, as tolerance does not build to all aspects of carisoprodol at the same rate. Over time, tolerance can build to this drug, so individuals will need larger amounts of the drug to experience symptom relief. Carisoprodol should only be used for two to three weeks at a time to avoid increases in tolerance that can play a role in overdose.
Confusion, delirium, or even hallucinations can cause individuals to exhibit bizarre behavior and become agitated.
Background. Carisoprodol, a centrally acting muscle relaxant with a high abuse potential, has barbiturate-like properties at the GABA-A receptor, leading to central nervous system depression and desired effects. Its tolerance and dependence has been previously demonstrated in an animal model, and withdrawal has been.
Many cases can be effectively managed with a short course of benzodiazepines or antipsychotic agents. However, abrupt cessation in a patient with a history of long-term and high-dose carisoprodol abuse may result in symptoms that are more difficult for providers to treat. Carisoprodol, a centrally acting muscle relaxant with a high abuse potential, has barbiturate-like properties at the GABA-A receptor, leading to central nervous system depression and desired effects. Its tolerance and dependence has been previously demonstrated in an animal model, and withdrawal has been described in several recent case reports.
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His improvement coincided with the addition of carisoprodol and phenobarbital to his treatment regimen. We present a case of a 34-year-old man with a long history of carisoprodol abuse who was found unresponsive after having ingested 7.5 grams of carisoprodol. He was given propofol, dexmedetomidine, fentanyl, ketamine, lorazepam, midazolam, quetiapine, and haloperidol, some at high-dose infusions, before his agitation and ventilator asynchrony could be controlled. He was intubated and admitted to the intensive care unit.
Trends show increasing emergency department presentations for drug-related disorders and treatment. This case highlights an uncommon case of carisoprodol withdrawal that may be encountered by emergency physicians, and demonstrates that benzodiazepines may not be sufficient to suppress severe withdrawal symptoms. Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal.
BACKGROUND: Carisoprodol is a skeletal muscle relaxant with the potential for abuse. A carisoprodol overdose is rarely considered fatal. Nevertheless, we encountered carisoprodol in several cases, prompting review of our experience. METHODS: We did a retrospective study of cases examined at the Jefferson County.
" South Med J. 1999 Apr;92(4):441. A comment on this article appears in " Use of carisoprodol by substance abusers to modify the effects of illicit drugs.
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Journal of Analytical Toxicology, Vol. 14, September/October 1990. I Case Report. Carisoprodol Concentrations from Different Anatomical. Sites: Three Overdose Cases. Ronald C. Backer*, Ross Zumwalt, Patricia McFeeley, and Sparks Veasey. Office of the Medical Investigator for the State of New Mexico and Department.