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SOMA (carisoprodol) Tablets. DESCRIPTION. SOMA (carisoprodol) Tablets are available as 250 mg and 350 mg round, white tablets. Carisoprodol is a white, crystalline powder, having a mild, characteristic odor and a bitter taste. It is slightly soluble in water; freely soluble in alcohol, in chloroform, and in acetone; and its.
Exposure of carisoprodol is higher in female than in male subjects (approximay 30-50% on a weight adjusted basis). Overall exposure of meprobamate is comparable between female and male subjects.
The major pathway of carisoprodol metabolism is via the liver by cytochrome enzyme CYP2C19 to form meprobamate. This enzyme exhibits genetic polymorphism (see Patients with Reduced CYP2C19 Activity below ).
The degree to which these properties of meprobamate contribute to the safety and efficacy of SOMA is unknown.
Carisoprodol, marketed under the brand name Somadril among others, is a prescription drug marketed since 1959. It is a centrally acting skeletal muscle relaxant of the carbamate class and produces all the effects associated with barbiturates. It is a prodrug and is both structurally and pharmacologically related to.
In the EU, the European Medicines Agency issued a release recommending member states suspend marketing authorization for this product in the treatment of acute (not chronic) back pain.
It is manufactured and marketed in the U.S. The diversion and abuse of the drug increased in the last decade. In the United States, carisoprodol is a Schedule IV controlled substance under the Controlled Substances Act of 1970. by Meda Pharmaceuticals and as of 2015, the cost for a typical course of the medication was less than US$25.
Treatment for physical withdrawal generally involves switching the patient to a long-acting benzodiazepine such as diazepam or clonazepam then slowly titrating them off the replacement drug compley at a rate which is both reasonably comfortable for the patient but rapid enough for the managing physician to consider the rate of progress acceptable (overly rapid dose reduction greatly increases the risk of patient non-compliance such as the abuse of illicitly obtained alternative sedatives and/or alcohol).
CLINICAL PHARMACOLOGY. Carisoprodol is a centrally acting skeletal muscle relaxant that does not directly relax skeletal muscles in man. The mode of action of carisprodol in relieving acute muscle spasm of local origin has not been clearly identified, but may be related to its sedative properties. In animals, carisoprodol.
The degree to which it contributes to the efficacy of carisoprodol is unknown. Carisoprodol is dialyzable by peritoneal and hemodialysis. Carisoprodol is metabolized in the liver and is excreted by the kidneys. One of the products of metabolism, is active as an anxiolytic.
This enzyme exhibits genetic polymorphism. Carisoprodol is metabolized in the liver via cytochrome P450 enzyme, CYP2C19. For Caucasians and Blacks, the prevalence of poor metabolizers is3-5-%. These levels are approximay 1/4 of those seen following a single 400 mg dose of meprobamate.
Find patient medical information for Carisoprodol Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
If you notice other effects not listed above, contact your doctor or pharmacist. This is not a complete list of possible side effects.
You may report side effects to Health Canada at. In Canada - Call your doctor for medical advice about side effects.
Do not start, stop, or change the dosage of any medicines without your doctor's approval. Drug interactions may change how your medications work or increase your risk for serious side effects. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Carisoprodol is a muscle relaxer that works by blocking pain sensations. Learn about side effects, interactions and indications.
Generic Name: carisoprodol (kar eye soe PROE dole) Brand Names: Soma, Vanadom.
Follow your doctor's dosing instructions very carefully. Carisoprodol is usually taken 3 times per day and at bedtime.
Misuse of habit-forming medicine can cause addiction, overdose, or death.
This medicine is not approved for use by anyone younger than 16 years old.
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Carisoprodol is a muscle relaxer that blocks pain sensations between the nerves and the brain.
Muscle Spasm cyclobenzaprine, Soma, tizanidine, baclofen, diazepam, Flexeril, Valium, methocarbamol, Zanaflex, Robaxin, Skelaxin, metaxalone, orphenadrine, chlorzoxazone, Lioresal, Norflex, Amrix, Lorzone, Parafon Forte DSC, Robaxin-750, Diastat, Comfort Pac with Cyclobenzaprine, Norgesic, Metaxall, More.
Stop using this medicine and call your doctor at once if you have:
high levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
Other brands: Soma, Vanadom.
seizure medicine - carbamazepine, oxcarbazepine; or.
antifungal medicine - ketoconazole, voriconazole;
Pregnancy Category Risk cannot be ruled out.
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Dizziness or severe drowsiness can cause falls or other accidents.